Patents and Inventions

  1. George Barany.  Xanthenylamide handle for use in peptide synthesis.  U.S. patent 5,117,009, filed August 31, 1990 and issued on May 26, 1992.  See also Chem. Abstr. 117, 8494u (1992), entitled “Preparation of xanthenylamide handle for use in peptide synthesis and support incorporating it.”  Licensed to MilliGen/Biosearch for several years.
  2. George Barany and Fernando Albericio.  Hypersensitive acid-labile handle for solid-phase peptide synthesis.  U.S. patent 5,196,566, filed August 31, 1990 and issued on March 23, 1993.  See also Chem. Abstr. 119, 139796h (1993).  Licensed to MilliGen/Biosearch for several years.
  3. George Barany, Fernando Albericio, Jane Chang, Samuel Zalipsky, and Nuria A. Solé  (amended list of inventors; Solé not part of original filing).  Polyethylene glycol derivatives for solid-phase applications.  U.S. patent 5,235,028, filed August 31, 1990, amended June 14, 1991 and September 16, 1991, and issued on August 10, 1993.  See also Chem. Abstr. 117, 172114r (1992).  Licensed to MilliGen/Biosearch and its successors.  As of January 2004, this patent and its “relatives” had generated over a quarter of a million dollars in royalties, and as such, ranked in the top 30 or so technologies developed in the history of the University of Minnesota.
  4. George Barany.  Xanthenylamide Handle for Use in Peptide Synthesis.  U.S. patent 5,306,562, filed May 15, 1992 and issued on April 26, 1994.  See also Chem. Abstr. 122, 82079g (1995).  Licensed to MilliGen/Biosearch for several years.
  5. George Barany, Jane Chang, Nuria A. Solé, Fernando Albericio, and Samuel Zalipsky.  Resin for solid-phase peptide synthesis and methods of making it.  European Patent 95112933.7-2109, filed August 27, 1991, and issued on October 24, 1995.  Please see description of U.S. patent.
  6. George Barany, Fernando Albericio, Jane Chang, Samuel Zalipsky, and Nuria A. Solé.  Polyethylene glycol derivatives for solid-phase applications.  European Patent 91916082.0-2109 0546055, filed August 27, 1991, and issued on July 10, 1996.  Please see description of U.S. patent.
  7. George Barany, Fernando Albericio, Nuria A. Solé, Jane Chang, and Samuel Zalipsky.  Polyethylene glycol derivatives for solid-phase applications.  U.S. patent 5,545,698 filed November 10, 1993, and issued August 13, 1996.  See also Chem. Abstr. 125, 223972 (1996).  Licensed to MilliGen/Biosearch and its successors; see earlier description for the financial impact of this invention.
  8. Maria Kempe and George Barany.  Highly cross-linked polymeric supports.  U.S. patent 5,656,707, filed June 16, 1995, and issued August 12, 1997.  See also Chem. Abstr. 126, 158526 (1997) and 131, 19959 (1999).  Licensed to Peptides International, Louisville, KY.
  9. George Barany, Robert P. Hammer, Karin Musier-Forsyth, Qinghong Xu, and Lin Chen.  Sulfurization of phosphorus-containing compounds.  U.S. patent 5,852,168, filed April 30, 1996, and issued December 22, 1998.  See also Chem. Abstr. 127, 359055 (1997), entitled “Sulfuration of DNA and RNA using disulfide-containing five-membered heterocycles.”  Licensed to PerSeptive Biosystems, Framingham, MA, and later to Applied Biosystems/Perkin Elmer Inc., Foster City, CA; non-exclusive license from January to July 2004 to Transgenomic, Inc., Omaha, NE. 
  10. Maria Kempe and George Barany.  Highly cross-linked polymeric supports.  U.S. patent 5,910,554, filed June 14, 1996, and issued June 8, 1999.  See also Chem. Abstr. 126, 158526 (1997) and 131, 19959 (1999).  Licensed to Peptides International, Louisville, KY.
  11. George Barany, Fernando Albericio, Knud J. Jensen, Michael F. Songster, Jordi Alsina [listed as Jorge Alsina-Fernandez], and Josef Vágner.  Support material for solid phase Organic Synthesis.  U.S. patent 5,917,015, filed June 18, 1996, and issued June 29, 1999.  See also Chem. Abstr. 131, 73977 (1999).  Licensed to PerSeptive Biosystems, Framingham, MA, and later to Applied Biosystems/Perkin Elmer Inc., Foster City, CA.
  12. David Cowburn, Jie Zheng, George Barany, and Qinghong Xu.  Consolidated ligands with increased affinities and methods of use thereof.  U.S. Provisional Application Serial No. 08/543,184, Attorney Docket Number 600-1-145, University of Minnesota Docket Number 95171, filed October 13, 1995.  See also Chem. Abstr. 128, 305398 (1999) entitled “Fusion proteins containing multiple domains binding to a target protein and their investigative and therapeutic uses.”
  13. Francis Barany, Matthew Lubin, Robert P. Hammer, and George Barany.  Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions.  U.S. patent 6,027,889, filed May 28, 1997 and issued February 22, 2000.  Licensed to Applied Biosystems/Perkin Elmer Inc., Foster City, CA.
  14. Francis Barany, Matthew Lubin, Phillip Belgrader, Robert P. Hammer, and George Barany.  Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions.  U.S. patent 6,268,148 filed November 15, 1999 and issued July 31, 2001.  Licensed to Applied Biosystems/Perkin Elmer Inc., Foster City, CA.
  15. Francis Barany, George Barany, Robert P. Hammer, Maria Kempe, Herman Blok, and Monib Zirvi.  Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays.  Australian Patent 735,440, filed February 5, 1997 and issued October 18, 2001.  More information below.
  16. Francis Barany, Norman P. Gerry, Nancy E. Witowski, Joseph Day, Robert P. Hammer, and George Barany.  Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays.  U.S. patent 6,506,594, filed March 16, 2000 and issued January 14, 2003.  Licensed to Applied Biosystems/Perkin Elmer Inc., Foster City, CA.
  17. George Barany, Fernando Albericio, Knud J. Jensen, Micheal F. Songster, Jordi Alsina, and Josef Vágner.  Support material for solid phase organic synthesis.  U.S. patent 6,566,494 filed May 11, 1999 and issued May 20, 2003.  Licensed to PerSeptive Biosystems, Framingham, MA, and later to Applied Biosystems/Perkin Elmer Inc., Foster City, CA.
  18. Francis Barany, Matthew Lubin, George Barany, and Robert P. Hammer.  Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions.  U.S. patent 6,797,470, filed July 30, 2001 and issued September 28, 2004.  Licensed to Applied Biosystems/Perkin Elmer Inc., Foster City, CA.
  19. Francis Barany, George Barany, Robert P. Hammer, Maria Kempe, Herman Blok, and Monib Zirvi.  Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays.  U.S. Provisional Application Serial No. 09/963,698, 09/963,920, and 09/986/527, filed February 9, 1996, and amended several times, most recently September 26, 2001 and November 9, 2001.  See also Chem. Abstr. 127, 214947 (1997) and Chem. Abstr. 137, 305710 (2002), the latter entitled “Detection of alleles of genes by a combination of allele‑specific ligase detection reaction and hybridization of ligation products to an addressable array.”  U.S. patent 6,852,487, filed February 4, 1997 and issued February 8, 2005.  Licensed to Applied Biosystems/Perkin Elmer Inc., Foster City, CA.
  20. Francis Barany, Norman P. Gerry, Nancy E. Witowski, Joseph Day, Robert P. Hammer, and George Barany.  Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays.  U.S. Provisional Application Serial No. 10/272,152, filed October 15, 2002.  Licensed to Applied Biosystems/Perkin Elmer Inc., Foster City, CA.
  21. Krzysztof Darlak and George Barany.  Polymer-supported reagent for the preparation of disulfide-bridged peptides.  U.S. Patent Application Serial No. 11/165,609, filed June 23, 2005.  Assigned to Peptides International, Inc., Louisville, KY.

Note: Only U.S. patents are listed, but almost all of these inventions have corresponding international patent protection.

 

Professor George Barany has 36 issued U.S. patents which span the fields of peptide synthesis resin supports (PEG-PS, CLEAR), peptide synthesis reagents and protecting groups (PAL, HAL, XAL, BAL, Clear-OX), technologies for the synthesis of antisense (phosphorothioate) DNA and RNA, as well as universal DNA arrays for detection of genetic diseases. 

 

Inventions

To date [information received from the Office of Technology Commercialization], these inventions have netted nearly \$1.4 million in royalties and licensing fees to the University of Minnesota, divided roughly equally between the peptide reagents and materials, and the DNA array work.  In addition, Barany’s work in the latter area has generated over \$2 billion in revenue for over a dozen commercial entities, and the University of Minnesota (along with Cornell University and Louisiana State University) is currently involved in litigation to recover appropriate compensation for this intellectual property.

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